research advances
Synopses of important developments in the field of structural biology and structural genomics, including advances from the Protein Structure Initiative. The featured articles and technical highlights are specially written for the Structural Biology Knowledgebase, while the research highlights are taken from NPG publications.
November 2011
featured articles
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An effective and cooperative dimer
NMR studies reveal the dimer interface of the effector domain (ED) of NS1A from influenza A virus and provide insight into how dimerization of the ED provides cooperative dsRNA binding and other functions of NS1A.
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A change to resistance
Two structures of NDM-1 β-lactamase show how this enzyme can confer resistance to many antibiotics.
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research highlights
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Broadly neutralizing anti-influenza mAbA large screen of human plasma cells leads to an antibody with pan-influenza cross-reactivity.
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Vaccines: Structure-based designStructural information guides design of a candidate vaccine for bacterial meningitis.
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technical highlights
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PDZ domains: sometimes it takes two
A systems approach reveals an unexpectedly high frequency of PDZ domain dimerization.
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Playing while you work
Foldit players successfully solve the crystal structure of a retroviral protease that had resisted previous determination.
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