research advances
Synopses of important developments in the field of structural biology and structural genomics, including advances from the Protein Structure Initiative. The featured articles and technical highlights are specially written for the Structural Biology Knowledgebase, while the research highlights are taken from NPG publications.
September 2011
featured articles
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Ribose production on demand
A previously unidentified enzymatic activity provides the driving force that leads to NADPH-independent ribose production.
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Breaking down the defenses
The structure of ISG15 bound to NS1B gives insight into the mechanism by which influenza B virus specifically targets humans.
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research highlights
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Anchored tailsCrystal structures of Get3 in complex with Get1 and Get2 yield insights into Get3-dependent membrane insertion of tail-anchored proteins.
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Cellular microbiology: Bacterial pea shootersA newly discovered tubular structure may help bacteria disperse membrane vesicles.
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technical highlights
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A fragmented approach to membrane protein structures
An innovative method combines NMR experiments and a database search to determine the structure of a challenging membrane protein.
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Solving a problem in phases
A new approach promises to eliminate a major hurdle to structure determination of membrane proteins using electron crystallography.
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