research advances
Synopses of important developments in the field of structural biology and structural genomics, including advances from the Protein Structure Initiative. The featured articles and technical highlights are specially written for the Structural Biology Knowledgebase, while the research highlights are taken from NPG publications.
August 2011
featured articles
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Raising a glass to GLIC
The pentameric ligand-gated ion channels (pLGICs) are known to be affected by alcohol in eukaryotes. Analyses of the prokaryotic GLIC suggest that it may be a good structural model for the effects of n-alcohols on pLGICs.
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Moving some metal
The crystal structure of a copper-transporting P1B-type ATPase provides valuable insight into how mutations contribute to Menkes' and Wilson's diseases.
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research highlights
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Nuclear membrane protein importLong intrinsically disordered linkers are required for the nuclear import of membrane proteins through the nuclear pore.
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Lipid-coated nanoporesCoating synthetic nanopores with fluid lipid bilayers is now suggested to improve usage for detection of molecules.
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technical highlights
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Molecular replacement by magnetic resonance
A new method coupled with accurate NMR structures yields highly reliable search models for molecular replacement.
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One from many
Xsolve utilizes many different approaches to streamline and enhance automated structure determination.
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