research advances
Synopses of important developments in the field of structural biology and structural genomics, including advances from the Protein Structure Initiative. The featured articles and technical highlights are specially written for the Structural Biology Knowledgebase, while the research highlights are taken from NPG publications.
May 2010
featured articles
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Treating sleeping sickness
A potential new drug kills the bloodstream parasite that causes this disease.
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Seek and destroy 8-oxoguanine
A systematic search reveals the first 8-oxoguanine deaminase.
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research highlights
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Anticancer drugs: RAF complexities spark cautionSeveral RAF inhibitors are in clinical trials, but three recently published papers indicate that the function of the RAS pathway in a patient's tumor will need to be assessed to avoid potential tumor-promoting effects of these inhibitors.
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Human microbiome: A gut feeling for diseaseThree studies showcase the growing interest in using genetics and genomics to understand how the huge numbers of bacteria that live in human guts influence our biology.
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technical highlights
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Some crystals like it hotHaving trouble crystallizing a protein from a thermophile? Try keeping your crystal plate warm.
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Modeling RNA structuresThe number of three-dimensional RNA structures is rapidly increasing, but are we getting close to being able to accurately predict new native structures?
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