about PSI
With the completion of the sequencing of the genomes of human and other organisms, attention has focused on the characterization and function of proteins, the products of genes. The availability of sequence data and the growing impact of structural biology on biomedical research have prompted scientific groups from several countries to undertake projects in the emerging field of structural genomics. The objective is to make these structures widely available for clinical and basic studies that will expand the knowledge of the role of proteins both in normal biological processes and in disease. The National Institute of General Medical Sciences (NIGMS) played a major role in the early planning for structural genomics and in 1999 organized a national program, the Protein Structure Initiative.
PSI:Biology Mission
The goal of the Protein Structure Initiative:Biology program is to apply the paradigm of high-throughput structure determination via highly organized networks of investigators to solve the three-dimensional structure of proteins and macromolecular complexes of substantial biological and biomedical problems and to use these structures to understand their biological function.
Latest Publications About the PSI
Entire issue of Acta Crys F devoted to JCSG
Wilson, IA, et al. (JCSG)
Acta Crys F, 2010 Oct; 66(10):1137-1405.
Read issue now
1,000 structures and more from the MCSG.
Lee D, de Beer TA, et al. (MCSG)
BMC Struct Biol. 2011 Jan 10;11:2.
[doi:10.1186/1472-6807-11-2]
Unmet challenges of structural genomics.
Chruszcz M, Domagalski M, et al. (MCSG)
Curr Opin Struct Biol. 2010 Oct;20(5):587-97.
[doi:10.1016/j.sbi.2010.08.001]
PSI:Biology-materials repository: a biologist's resource for protein expression plasmids.
Cormier CY, Park JG, et al. (PSI-MR)
J Struct Funct Genomics. 2011 Mar 1. [Epub ahead of print]
[doi:10.1007/s10969-011-9100-8]
See more publications by the PSI in our Publications Portal.
PSI Funding Opportunities
Listed here are active funding opportunities sponsored by the NIGMS/NIH.
Request For Applications
none at this time
Program Announcements
- New! High-Throughput-Enabled Structural Biology Research (U01)
PAR-11-176, expiration: September 8, 2013 - Technology Development for High-Throughput Structural Biology Research (R01)
PAR-10-073, expiration: January 8, 2013 - Technology Development for High-Throughput Structural Biology Research (P01)
PAR-10-074, expiration: May 8, 2013 - Technology Development for Protein Modeling (P01)
PAR-10-075, expiration: May 8, 2013 - Technology Development for Protein Modeling (R01)
PAR-10-076, expiration: January 8, 2013
Notices and Policies
Sponsored
- Administrative Supplements for Functional Studies Based on Results Obtained in the Protein Structure Initiative
NOT-GM-08-123, released March 13, 2008
Participating
none at this time
PSI:Biology Organization
The following links to the National Institute of General Medical Sciences, the NIH component that supports the PSI, provide the organizational details of the PSI-funded centers, steering committee, program staff, and advisory committee.
PSI:Biology Advisory Committee
PSI:Biology Policies
Policy on Release of Structures
PSI Policies on Community-Nominated Targets
PSI-2 and PSI:Biology Reports
Report from the PSI:Biology Advisory Committee, Dec 2010 (PDF | 48 Kb)
Report from the PSI Advisory Committee, Dec 2009 (PDF | 14 Kb)
Opportunities for Structural Genomics Beyond 2010 : Creating Partnerships for the Future, 2009 (PDF | 4.1 Mb)
Report of the Future Structural Genomics Initiatives Meeting, 2009 (HTML)
Report of the Protein Structure Initiative Assessment Panel, 2007 (HTML)
Assessment of the Protein Structure Initiative, 2007 (HTML)
PSI SBKB People
The Protein Structure Initiative Structural Biology Knowledgebase (SBKB) is a Resource Center within the PSI Program. The goal of the Structural Biology Knowledgebase is to turn the products of the Protein Structure Initiative effort into knowledge that is important for understanding living systems and disease.
PSI SBKB staff:
Helen M. Berman (Director, Rutgers University)
Li Chen
James Chun
Margaret J. Gabanyi
David Micallef
Ezra Peisach
Martha Quesada
Raship Shah
Wendy Tao
John Westbrook
PSI Resource Leaders:
Models: Torsten Schwede, Swiss Institute of Bioinformatics/Biozentrum University of Basel
Experimental Data Tracking: David Micallef, Rutgers University
Technology: Paul Adams, Lawrence Berkeley Laboratory
Publications: Wladek Minor, University of Virginia
Material Repository: Josh LaBaer, ASU Biodesign Institute, Arizona State University