New Web Portal to Advance Wide Range of Protein Studies
The Protein Structure Initiative (PSI), an effort supported by the National Institutes of Health (NIH), has launched an online resource that will enable scientists from across biomedical disciplines to easily access a wealth of information about proteins and to sp ...
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Welcome to the PSI SGKB Portal!
To get started please read our FAQ. Please send comments to
comments@psi-structuralgenomics.org
The Protein Structure Initiative Structural Genomics Knowledgebase (PSI SGKB) is designed to turn the products of the Protein Structure Initiative effort into knowledge that is important for understanding living systems and disease. The PSI SGKB is a key resource in the advancement of biology, biochemistry, functional genomics, pharmacology, bioinformatics, education and clinical medicine.
Use the following query form to search the PSI SGKB by one-letter code protein sequence, keyword or Protein Data Bank (PDB) identifier code. (Example Sequence Search)| News | Featured PSI Structures |
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ChronophinThe cell is a busy place with thousands of things happening at once. This requires constant communication and careful regulation. Phosphorylation is a perfect way to control these many simultaneous molecular tasks. Phosphate groups... Read more » |
| Functional Sleuth | Technical Highlight |
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Functional Sleuth presents PSI structures lacking full functional annotation.
Explore these protein structures and add your input about the possible functions.
Begin exploring »
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Chaperones for Crystallization
We have developed and implemented a high throughput process to produce crystallization chaperones to assist in crystallizing difficult protein and RNA targets. In particular, we are focusing on recalcitrant protein complexes, membrane proteins, and functional RNAs. The crystallization chaperones are based on three scaffold types: Fabs (~550 amino acids), VHH domains ( ... Read more » |